Ways to improve cancer diagnosis and identify the risk of developing and recurring cervical cancer

Abstract

Аnnotation

Cervical cancer is the fourth leading cause of death among women and is the third most common cancer among women worldwide.

Purpose: to determine the risk factors and the time interval for progression and relapse after complex treatment (neoadjuvant chemotherapy + radical hysterectomy + combined radiation therapy) in patients with cervical cancer.

Materials and methods: A retrospective case control study was carried out, the medical histories of patients with stage IB-IIA cervical cancer and a history of radical hysterectomy with dissection of pelvic lymph nodes followed by pelvic radiation therapy at a dose of ≥40 Gy were analyzed, registered from 2010 to 2019 in the Republic of Kazakhstan, Shymkent ( n = 883), the cancer center covers a representative population of the region. Over the past 10 years, the survival rate and risk factors for recurrence were analyzed depending on the age of the patients, the stage of the disease and the morphological structure.

Conclusions: According to the data obtained, out of 884 patients with cervical cancer, progression in 74 (79.5) women and relapse occurred in 19 women (20.4%). Recurrences of cervical cancer more often occurred in women of the age groups from 45 to 50 (28.4%) and from 50 to 60 (26.3%) years.

Key words: Cervical cancer, adjuvant chemistry and radiation therapy, Risk factor, progression and relapse.