STUDY OF THE ONCOLOGICAL PROCESS INFLUENCE ON OVARIAN RESERVE

Abstract

Relevance: The problem of reproductive health of women suffering from oncological diseases is becoming increasingly important in the context of modern healthcare. Breast cancer is increasingly diagnosed in young women of reproductive age, which creates a need to study the impact of these diseases on the ovarian reserve, which is critical for the ability to conceive.
This study aims to assess the impact of breast cancer on the ovarian reserve of women of reproductive age, as well as to develop strategies for preserving fertility.
Methods: The study involved 80 patients with oncological diseases and 61 conditionally healthy women in the Control Group. The ovarian reserve was assessed by ultrasound examination with antral follicle counting and hormonal status analysis (FSH, LH, AMH).
Results: The average number of antral follicles in the main group was lower (Me=6) compared to the Control Group (Me=9), which was statistically significant (p<0.001). FSH and AMH levels also showed sig-nificant differences between the groups, confirming the negative impact of cancer on the ovarian reserve. The LH level, however, remained stable in both groups (p=0.661).
Conclusions: The study showed that cancer significantly impacts the ovarian reserve, reducing women’s reproductive capabilities. These data highlight the need to integrate fertility preservation strategies, including oocyte cryopreservation, into treatment programs. An interdisciplinary approach that combines the efforts of oncologists and reproductive specialists is important to achieve better clinical and personal outcomes for patients. Further research will help to deepen the understanding of the mechanisms affecting the ovarian re-serve in the context of cancer.